A guidebook developed by European Group for the Immunological Characterization of Leukemias (EGIL) diagnoses hematologic malignancies uniformly and sheds light on the characterization of acute leukemias, in relation to expression
نویسندگان
چکیده
The most common hematological malignant diseases of the childhood are acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). Minimal residual disease is gaining importance nowadays both for therapy efficacy follow up and relapse risk estimation. Owing to fast technological developments, minimal residual disease (MRD) can be evaluated both by molecular and flow cytometric methods, precisely. This review focuses on flow cytometry methodology and its contributions to MRD detection as well as advantages and disadvantages of flow
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The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia
MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...
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